Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine

Tatsuyuki Yoshii; Yingying Geng; Shelly Peyton; Arthur M Mercurio; Vincent M Rotello

doi:10.1016/j.drudis.2016.05.011

Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine

Drug Discov Today. 2016 Sep;21(9):1489-1494. doi: 10.1016/j.drudis.2016.05.011. Epub 2016 May 26.

Authors

Tatsuyuki Yoshii¹, Yingying Geng², Shelly Peyton³, Arthur M Mercurio⁴, Vincent M Rotello⁵

Affiliations

¹ Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
² Molecular and Cellular Biology Program, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
³ Department of Chemical Engineering, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA. Electronic address: speyton@ecs.umass.edu.
⁴ Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: Arthur.Mercurio@umassmed.edu.
⁵ Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA; Molecular and Cellular Biology Program, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA. Electronic address: rotello@chem.umass.edu.

Abstract

Metastasis, drug resistance and recurrence in cancer are regulated by the tumor microenvironment. This review describes recent advances in understanding how cancer cells respond to extracellular environmental cues via integrins, how to build engineered microenvironments to study these interactions in vitro and how nanomaterials can be used to detect and target tumor microenvironments.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Biomechanical Phenomena
Humans
Integrins / physiology
Nanomedicine
Nanostructures
Neoplasms / pathology*
Tumor Microenvironment

Substances

Integrins

Abstract

Publication types

MeSH terms

Substances

Grants and funding