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. 2016 Aug;26(8):565-568.
doi: 10.1016/j.tcb.2016.05.002. Epub 2016 May 27.

Does Longer Lifespan Mean Longer Healthspan?

Malene Hansen  1 , Brian K Kennedy  2
Affiliations

Does Longer Lifespan Mean Longer Healthspan?

Malene Hansen et al. Trends Cell Biol. 2016 Aug.

Abstract

Once thought to be impossible, it is now clear that changing the activity of several conserved genetic pathways can lead to lifespan extension in experimental organisms. In humans, however, the goal is to extend healthspan, the functional and disease-free period of life. Are the current pathways to lifespan extension also improving healthspan?

Keywords: Caenorhabditis elegans; TOR signaling; aging; insulin/IGF-1 signaling; longevity; mice.

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Figures

Figure 1
Figure 1. Schematic illustrating effects of lifespan extension on healthspan extension
In A-D, lifespan extension is accompanied by differential effects on morbidity onset, thus affecting healthspan in different ways. ‘Chronological’ and ‘Proportional’ are used in the text to describe specific effects of longevity paradigms on healthspan. Evidence from the reduced insulin/IGF-1 and TOR signaling paradigms have provided evidence in support of B and C.
See this image and copyright information in PMC

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