Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease

World J Gastroenterol. 2016 May 28;22(20):4926-35. doi: 10.3748/wjg.v22.i20.4926.


Aim: To evaluate the performance of elastography by ultrasound with acoustic radiation force impulse (ARFI) in determining fibrosis stage in patients with alcoholic liver disease (ALD) undergoing alcoholic detoxification in relation to biopsy.

Methods: Eighty-three patients with ALD undergoing detoxification were prospectively enrolled. Each patient underwent ARFI imaging and a liver biopsy on the same day. Fibrosis was staged according to the METAVIR scoring system. The median of 10 valid ARFI measurements was calculated for each patient.

Results: Sixty-nine males and thirteen females (one patient excluded due to insufficient biopsy size) were assessed with a mean alcohol consumption of 132.4 ± 128.8 standard drinks per week and mean cumulative year duration of 17.6 ± 9.5 years. Sensitivity and specificity were respectively 82.4% (0.70-0.95) and 83.3% (0.73-0.94) (AUROC = 0.87) for F ≥ 2 with a cut-off value of 1.63m/s; 82.4% (0.64-1.00) and 78.5% (0.69-0.89) (AUROC = 0.86) for F ≥ 3 with a cut-off value of 1.84m/s; and 92.3% (0.78-1.00] and 81.6% (0.72-0.90) (AUROC = 0.89) for F = 4 with a cut-off value of 1.94 m/s.

Conclusion: ARFI is an accurate, non-invasive and easy method for assessing liver fibrosis in patients with ALD undergoing alcoholic detoxification.

Keywords: Acoustic radiation force impulse; Alcoholic liver disease; Elastography; Fibrosis; Non-invasive.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adult
  • Area Under Curve
  • Biopsy
  • Elasticity Imaging Techniques*
  • Female
  • Humans
  • Liver / diagnostic imaging*
  • Liver / pathology
  • Liver Cirrhosis, Alcoholic / diagnostic imaging*
  • Liver Cirrhosis, Alcoholic / pathology
  • Liver Cirrhosis, Alcoholic / therapy
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prospective Studies
  • ROC Curve
  • Reproducibility of Results
  • Severity of Illness Index