Fabrication of 3D Biomimetic Microfluidic Networks in Hydrogels

Keely A Heintz; Michael E Bregenzer; Jennifer L Mantle; Kelvin H Lee; Jennifer L West; John H Slater

doi:10.1002/adhm.201600351

Fabrication of 3D Biomimetic Microfluidic Networks in Hydrogels

Adv Healthc Mater. 2016 Sep;5(17):2153-60. doi: 10.1002/adhm.201600351. Epub 2016 May 30.

Authors

Keely A Heintz¹, Michael E Bregenzer¹, Jennifer L Mantle^{2

3}, Kelvin H Lee^{2

3}, Jennifer L West⁴, John H Slater^{5

6}

Affiliations

¹ Department of Biomedical Engineering, University of Delaware, 150 Academy Street161 Colburn Lab, Newark, DE, 19716, USA.
² Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Colburn Lab, Newark, DE, 19716, USA.
³ Delaware Biotechnology Institute, 15 Innovation Way, Newark, DE, 19711, USA.
⁴ Department of Biomedical Engineering, Duke University, 101 Science Drive, 1427 Fitzpatrick Center, Durham, NC, 27708, USA.
⁵ Department of Biomedical Engineering, University of Delaware, 150 Academy Street161 Colburn Lab, Newark, DE, 19716, USA. jhslater@udel.edu.
⁶ Delaware Biotechnology Institute, 15 Innovation Way, Newark, DE, 19711, USA. jhslater@udel.edu.

Abstract

A laser-based hydrogel degradation technique is developed that allows for local control over hydrogel porosity, fabrication of 3D vascular-derived, biomimetic, hydrogel-embedded microfluidic networks, and generation of two intertwining, yet independent, microfluidic networks in a single construct.

Keywords: biomimetic; laser-based degradation; microfluidic; tissue engineering; vascularized constructs.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Biomimetic Materials / chemistry*
Hydrogels / chemistry*
Lab-On-A-Chip Devices*

Substances

Hydrogels

Abstract

Publication types

MeSH terms

Substances

Grant support