Perangustols A and B, a pair of new azaphilone epimers from a marine sediment-derived fungus Cladosporium perangustm FS62

J Asian Nat Prod Res. 2016 Nov;18(11):1024-9. doi: 10.1080/10286020.2016.1181623. Epub 2016 May 30.

Abstract

A pair of new azaphilone epimers, perangustols A-B (1-2), and two new natural products (3-4), together with two known metabolites (5-6) were isolated from the culture of the marine sediment-derived fungus Cladosporium perangustum FS62. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The isolated compounds (1-6) were evaluated for their cytotoxic activities against the SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. Nonetheless, no significant activity was observed.

Keywords: Cladosporium perangustum; Marine fungus; azaphilone; perangustols.

MeSH terms

  • Benzopyrans / chemistry*
  • Benzopyrans / isolation & purification*
  • Benzopyrans / pharmacology
  • Cell Line, Tumor
  • Cladosporium / chemistry*
  • Drug Screening Assays, Antitumor
  • Geologic Sediments
  • Hep G2 Cells
  • Humans
  • Marine Biology
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Pigments, Biological / chemistry*
  • Pigments, Biological / isolation & purification*
  • Pigments, Biological / pharmacology

Substances

  • Benzopyrans
  • Pigments, Biological
  • azaphilone
  • perangustol A