Unilateral ultra-brief pulse electroconvulsive therapy for depression in Parkinson's disease

Acta Neurol Scand. 2017 Apr;135(4):407-411. doi: 10.1111/ane.12614. Epub 2016 May 31.

Abstract

Objectives: Electroconvulsive therapy (ECT) has demonstrated efficacy in treating core symptoms of Parkinson's disease (PD); however, widespread use of ECT in PD has been limited due to concern over cognitive burden. We investigated the use of a newer ECT technology known to have fewer cognitive side effects (right unilateral [RUL] ultra-brief pulse [UBP]) for the treatment of medically refractory psychiatric dysfunction in PD.

Materials and methods: This open-label pilot study included 6 patients who were assessed in the motoric, cognitive, and neuropsychiatric domains prior to and after RUL UBP ECT. Primary endpoints were changes in total score on the HAM-D-17 and GDS-30 rating scales.

Results: Patients were found to improve in motoric and psychiatric domains following RUL UBP ECT without cognitive side effects, both immediately following ECT and at 1-month follow-up.

Conclusions: This study demonstrates that RUL UBP ECT is safe, feasible, and potentially efficacious in treating multiple domains of PD, including motor and mood, without clear cognitive side effects.

Keywords: Parkinson's disease; depression; electroconvulsive therapy; ultra-brief pulse.

MeSH terms

  • Aged
  • Depression / etiology
  • Depression / therapy*
  • Electroconvulsive Therapy / adverse effects*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / complications*
  • Parkinson Disease / therapy
  • Pilot Projects