Slippery signaling: Palmitoylation-dependent control of neuronal kinase localization and activity

Mol Membr Biol. Aug-Dec 2015;32(5-8):179-88. doi: 10.1080/09687688.2016.1182652. Epub 2016 May 31.

Abstract

Modification of proteins with the lipid palmitate, a process called palmitoylation, is important for the normal function of neuronal cells. However, most attention has focused on how palmitoylation regulates the targeting and trafficking of neurotransmitter receptors and non-enzymatic scaffold proteins. In this review we discuss recent studies that suggest that palmitoylation also plays additional roles in neurons by controlling the localization, interactions and perhaps even the activity of protein kinases that play key roles in physiological neuronal regulation and in neuropathological processes.

Keywords: Glutamate receptor; acylation; palmitoylation; phosphorylation; signaling.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Lipoylation*
  • Neurons / enzymology*
  • Protein Kinases / metabolism*
  • Protein Transport
  • Signal Transduction*

Substances

  • Protein Kinases