Eruptive nevi associated with medications (ENAMs)

J Am Acad Dermatol. 2016 Nov;75(5):1045-1052. doi: 10.1016/j.jaad.2016.04.064. Epub 2016 May 27.


Eruptive melanocytic nevi have been reported in association with severe blistering diseases, renal transplantation, malignancy, AIDS, and medications. Eruptive nevi associated with medications have been reported with increasing frequency. Of particular interest are eruptive nevi associated with medications developing in association with biologic therapies, which we anticipate will continue to become more common as use of these medications continues to increase. We searched the databases PubMed/MEDLINE, Cochrane, and Cumulative Index to Nursing and Allied Health Literature for associated medications using the terms "eruptive nevi," "melanocytic + medications," and "nevi + medications" for relevant articles. We report the summary of our findings, which were used in defining what constitutes an eruptive nevi associated with medication and developing a classification system by medication type.

Keywords: adverse effects; azathioprine; combination chemotherapy; drug reactions; eruptive nevi; eruptive nevi associated with medications; medication reactions; medication-associated nevi eruptions; medication-associated reactions; melanocytic nevi; nevi; nevi eruptions; rituximab.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal / adverse effects*
  • Antineoplastic Agents / adverse effects*
  • Drug Eruptions / epidemiology
  • Drug Eruptions / etiology*
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Neoplasms, Multiple Primary / chemically induced*
  • Neoplasms, Multiple Primary / epidemiology
  • Neoplasms, Second Primary / chemically induced
  • Neoplasms, Second Primary / epidemiology
  • Nevus, Pigmented / chemically induced*
  • Nevus, Pigmented / epidemiology
  • Risk
  • Skin Neoplasms / chemically induced*
  • Skin Neoplasms / epidemiology


  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Immunosuppressive Agents