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Review
. 2016 May 31;9(430):fs11.
doi: 10.1126/scisignal.aaf4630.

Hydroxylation-independent HIF-1α Stabilization Through PKA: A New Paradigm for Hypoxia Signaling

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Review

Hydroxylation-independent HIF-1α Stabilization Through PKA: A New Paradigm for Hypoxia Signaling

Eóin N McNamee et al. Sci Signal. .

Abstract

In this issue of Science Signaling, Bullen et al demonstrate that protein kinase A (PKA) phosphorylates and stimulates the transcriptional activity of hypoxia-inducible transcription factor-1α (HIF-1α). This finding may have implications in diseases processes that occur at the interface of hypoxia and inflammation, where HIF-1α stabilization can function to dampen hypoxia-driven inflammation.

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