Recent Advances in Developing Small Molecules Targeting Nucleic Acid

Int J Mol Sci. 2016 May 30;17(6):779. doi: 10.3390/ijms17060779.


Nucleic acids participate in a large number of biological processes. However, current approaches for small molecules targeting protein are incompatible with nucleic acids. On the other hand, the lack of crystallization of nucleic acid is the limiting factor for nucleic acid drug design. Because of the improvements in crystallization in recent years, a great many structures of nucleic acids have been reported, providing basic information for nucleic acid drug discovery. This review focuses on the discovery and development of small molecules targeting nucleic acids.

Keywords: DNA drug discovery; RNA drug discovery; nucleic acids; nucleic acids targeting; small molecules.

Publication types

  • Review

MeSH terms

  • Crystallization
  • Drug Design
  • Humans
  • Nucleic Acid Conformation
  • Nucleic Acids / chemistry*
  • Small Molecule Libraries / chemistry*


  • Nucleic Acids
  • Small Molecule Libraries