Basic Overview of Current Immunotherapy Approaches in Cancer

Am Soc Clin Oncol Educ Book. 2016;35:298-308. doi: 10.1200/EDBK_156572.


Recent success of immunotherapy strategies such as immune checkpoint blockade in several malignancies has established the role of immunotherapy in the treatment of cancer. Cancers use multiple mechanisms to co-opt the host-tumor immune interactions, leading to immune evasion. Our understanding of the host-tumor interactions has evolved over the past few years and led to various promising new therapeutic strategies. This article will focus on the basic principles of immunotherapy, novel pathways/agents, and combinatorial immunotherapies.

Publication types

  • Review

MeSH terms

  • Cell Cycle Checkpoints / immunology*
  • Humans
  • Immunotherapy*
  • Neoplasms / genetics
  • Neoplasms / immunology*
  • Neoplasms / therapy