Catalytic Enantioselective Desymmetrization Reactions to All-Carbon Quaternary Stereocenters

Chem Rev. 2016 Jun 22;116(12):7330-96. doi: 10.1021/acs.chemrev.6b00094. Epub 2016 Jun 2.


This Review summarizes the advances in the construction of all-carbon quaternary stereocenters via catalytic enantioselective desymmetrization of prochiral and meso-compounds, highlights the power and potential of this strategy in the total synthesis of natural products and biologically active compounds, and outlines the synthetic opportunities still available.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carbon / chemistry*
  • Catalysis
  • Cyclization
  • Stereoisomerism


  • Carbon