Early growth response-1 in the pathogenesis of cardiovascular disease

J Mol Med (Berl). 2016 Jul;94(7):747-53. doi: 10.1007/s00109-016-1428-x. Epub 2016 Jun 1.

Abstract

This article reviews the regulatory roles of the immediate-early gene product and prototypic zinc finger transcription factor, early growth response-1 in models of cardiovascular pathobiology, focusing on insights using microRNA, DNAzymes, small hairpin RNA, small interfering RNA, oligonucleotide decoy strategies and mice deficient in early growth response-1.

Keywords: Egr-1; Restenosis; Smooth muscle cells; Transcription factors.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cardiovascular Diseases / genetics*
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / pathology
  • DNA, Catalytic / genetics
  • DNA, Catalytic / metabolism
  • Disease Models, Animal
  • Early Growth Response Protein 1 / antagonists & inhibitors
  • Early Growth Response Protein 1 / genetics*
  • Early Growth Response Protein 1 / metabolism
  • Gene Expression Regulation*
  • Humans
  • Mice
  • Mice, Knockout
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Muscle, Smooth, Vascular / metabolism
  • Muscle, Smooth, Vascular / pathology
  • Oligodeoxyribonucleotides / genetics
  • Oligodeoxyribonucleotides / metabolism
  • RNA, Messenger / antagonists & inhibitors*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / metabolism
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / metabolism

Substances

  • DNA, Catalytic
  • EGR1 protein, human
  • Early Growth Response Protein 1
  • Egr1 protein, mouse
  • MIRN145 microRNA, human
  • MicroRNAs
  • Oligodeoxyribonucleotides
  • RNA, Messenger
  • RNA, Small Interfering
  • Transforming Growth Factor beta