Abstract
This article reviews the regulatory roles of the immediate-early gene product and prototypic zinc finger transcription factor, early growth response-1 in models of cardiovascular pathobiology, focusing on insights using microRNA, DNAzymes, small hairpin RNA, small interfering RNA, oligonucleotide decoy strategies and mice deficient in early growth response-1.
Keywords:
Egr-1; Restenosis; Smooth muscle cells; Transcription factors.
Publication types
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Review
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cardiovascular Diseases / genetics*
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Cardiovascular Diseases / metabolism
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Cardiovascular Diseases / pathology
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DNA, Catalytic / genetics
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DNA, Catalytic / metabolism
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Disease Models, Animal
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Early Growth Response Protein 1 / antagonists & inhibitors
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Early Growth Response Protein 1 / genetics*
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Early Growth Response Protein 1 / metabolism
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Gene Expression Regulation*
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Humans
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Mice
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Mice, Knockout
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MicroRNAs / genetics*
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MicroRNAs / metabolism
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Muscle, Smooth, Vascular / metabolism
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Muscle, Smooth, Vascular / pathology
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Oligodeoxyribonucleotides / genetics
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Oligodeoxyribonucleotides / metabolism
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RNA, Messenger / antagonists & inhibitors*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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RNA, Small Interfering / genetics
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RNA, Small Interfering / metabolism
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Transforming Growth Factor beta / genetics
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Transforming Growth Factor beta / metabolism
Substances
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DNA, Catalytic
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EGR1 protein, human
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Early Growth Response Protein 1
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Egr1 protein, mouse
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MIRN145 microRNA, human
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MicroRNAs
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Oligodeoxyribonucleotides
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RNA, Messenger
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RNA, Small Interfering
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Transforming Growth Factor beta