Autoantibodies, complement and type I interferon as biomarkers for personalized medicine in SLE

Lupus. 2016 Jul;25(8):823-9. doi: 10.1177/0961203316640922.


Systemic lupus erythematosus (SLE) can be a mysterious disease, presenting with extremely divergent clinical phenotypes. Already, biomarkers are very helpful tools for diagnosis, assessment and monitoring of disease activity, differential diagnosis of clinical manifestations, prediction of the disease course and stratified therapy, and they hold the key to personalized medicine in SLE. We summarize the clinical information that can only be supplied by autoantibodies, complement components and interferon biomarkers in this diverse disease.

Keywords: Anti-DNA antibodies; Type I interferon; biomarker; companion diagnostics; complement components.

MeSH terms

  • Autoantibodies / blood*
  • Biomarkers / blood
  • Complement System Proteins / analysis*
  • Humans
  • Interferon Type I / blood*
  • Lupus Erythematosus, Systemic / blood*
  • Lupus Erythematosus, Systemic / diagnosis*
  • Lupus Erythematosus, Systemic / drug therapy
  • Precision Medicine
  • Severity of Illness Index


  • Autoantibodies
  • Biomarkers
  • Interferon Type I
  • Complement System Proteins