Single dose treatment of malaria - current status and perspectives

Expert Rev Anti Infect Ther. 2016 Jul;14(7):669-78. doi: 10.1080/14787210.2016.1192462. Epub 2016 Jun 7.


Introduction: Despite increased international efforts for control and ultimate elimination, malaria remains a major health problem. Currently, artemisinin-based combination therapies are the treatment of choice for uncomplicated malaria exhibiting high efficacy in clinical trial settings in sub-Saharan Africa. However, their administration over a three-day period is associated with important problems of treatment adherence resulting in markedly reduced effectiveness of currently recommended antimalarials under real world settings.

Areas covered: Antimalarial drug candidates and antimalarial drug combinations currently under advanced clinical development for the indication as single dose antimalarial therapy. Expert commentary: Several new drug candidates and combinations are currently undergoing pivotal proof-of-concept studies or clinical development programmes. The development of a single dose combination therapy would constitute a breakthrough in the control of malaria. Such an innovative treatment approach would simultaneously close the effectiveness gap of current three-day therapies and revolutionize population based interventions in the context of malaria elimination campaigns.

Keywords: AQ-13; DSM265; KAE609; KAF156; OZ277; OZ439; Single dose treatment; effectiveness; falciparum; ferroquine; malaria; naphthoquine; piperaquine; tafenoquine.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimalarials / administration & dosage*
  • Antimalarials / adverse effects
  • Antimalarials / pharmacokinetics
  • Antimalarials / therapeutic use
  • Clinical Trials as Topic
  • Drug Administration Schedule
  • Drug Combinations
  • Humans
  • Malaria / drug therapy*
  • Malaria / epidemiology*
  • Malaria / parasitology
  • Malaria / prevention & control
  • Medication Adherence
  • Treatment Outcome


  • Antimalarials
  • Drug Combinations