Objective: To study the chemical constituents in Periplaneta americana.
Methods: The chemical constituents were separated and purified by chromatographic methods after solvent extraction and identified by spectroscopic analyses.
Results: Ten compounds were isolated from Periplaneta americana and identified as following: 8-hydroxy-3,4-dihydroquinolin-2 (1H)-one (1), cyclo-( L-Phe-L-Pro) (2), cyclo-(Pro-Ile) (3), cyclo-(L-Pro-D-Leu) (4), brevianamide F (5), cyclo-(Ile-Ala) (6), cyclo-( L-Val-L-Pro) (7), cyclo-(L-Pro-L-Tyr) (8), cyclo-(Trp-Val)-dipeptide (9), and (-)-(1S, 3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (10).
Conclusion: Compounds 2 - 9 are isolated from Periplaneta americana for the first time.