Engineering Paper-Based Sensors for Zika Virus

Trends Mol Med. 2016 Jul;22(7):529-530. doi: 10.1016/j.molmed.2016.05.009. Epub 2016 May 30.


The emergence of Zika virus (ZIKV) infections in Latin America and Southeast Asia has created an urgent need for new, simple, yet sensitive, diagnostic tests. We highlight recent work using paper-based sensors coupled with CRISPR/Cas9 to detect ZIKV RNA as a new approach to achieve rapid development and deployment of field-ready diagnostics for emerging infectious diseases.

Keywords: CRISPR/Cas9; emerging infectious diseases; molecular diagnostics; paper microfluidics; toehold sensors.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • CRISPR-Cas Systems*
  • Humans
  • Microfluidic Analytical Techniques / methods*
  • Paper
  • RNA, Viral / genetics*
  • RNA, Viral / isolation & purification
  • Zika Virus / genetics*
  • Zika Virus / isolation & purification*
  • Zika Virus Infection / diagnosis*


  • RNA, Viral