Efficacy of the Hydroalcoholic Extract of Tribulus terrestris on the Serum Glucose and Lipid Profile of Women With Diabetes Mellitus: A Double-Blind Randomized Placebo-Controlled Clinical Trial

J Evid Based Complementary Altern Med. 2016 Oct;21(4):NP91-7. doi: 10.1177/2156587216650775. Epub 2016 Jun 2.


Aim: Considering traditional use of Tribulus terrestris in diabetes and proven antihyperglycemic and antihyperlipidemic effects of T terrestris in animal studies, we aimed to evaluate the efficacy of the hydroalcoholic extract of T terrestris on the serum glucose and lipid profile of women with non-insulin-dependent diabetes mellitus.

Methods: Ninety-eight women with diabetes mellitus type 2 were randomly allocated to receive the T terrestris (1000 mg/d) or placebo for 3 months. The patients were evaluated in terms of the fasting blood glucose, 2-hour postprandial glucose, glycosylated hemoglobin, and lipid profile.

Results: Tribulus terrestris showed a significant blood glucose-lowering effect in diabetic women compared to placebo (P < .05). Also, the total cholesterol and low-density lipoprotein of T terrestris group was significantly reduced compared with placebo, while no significant effect was observed in the triglyceride and high-density lipoprotein levels.

Conclusions: The study showed preliminary promising hypoglycemic effect of T terrestris in women with diabetes mellitus type 2.

Keywords: Tribulus terrestris; diabetes mellitus; herbal medicine; traditional medicine.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Blood Glucose / drug effects*
  • Diabetes Mellitus, Type 2 / metabolism*
  • Female
  • Humans
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / pharmacology*
  • Lipids / blood*
  • Middle Aged
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Tribulus / chemistry*


  • Blood Glucose
  • Hypoglycemic Agents
  • Lipids
  • Plant Extracts