Leishmania DNA Replication Timing: A Stochastic Event?

Trends Parasitol. 2016 Oct;32(10):755-757. doi: 10.1016/j.pt.2016.05.011. Epub 2016 May 30.


For eukaryotic genomes, DNA synthesis initiates at multiple discrete regions known as replication origins in a dynamic yet regulated manner to ensure genomic stability. Two recent studies using different approaches reveal few Leishmania origins and that origin firing may proceed in a mainly stochastic manner.

Keywords: DNA replication; Leishmania; aneuploidy; origin of replication; stochastic timing.

Publication types

  • Comment

MeSH terms

  • Animals
  • DNA Replication Timing*
  • Drug Delivery Systems
  • Genomic Instability*
  • Humans
  • Leishmania / genetics*
  • Leishmaniasis / parasitology
  • Leishmaniasis / prevention & control
  • Replication Origin / genetics