Acute respiratory compromise on inpatient wards in the United States: Incidence, outcomes, and factors associated with in-hospital mortality

Resuscitation. 2016 Aug:105:123-9. doi: 10.1016/j.resuscitation.2016.05.014. Epub 2016 May 30.


Aim: To estimate the United States' incidence and in-hospital mortality of acute respiratory events on inpatient wards and to identify factors associated with mortality.

Methods: This is an analysis of prospectively collected data from the Get With the Guidelines(®) - Resuscitation registry. We included adult patients with index acute respiratory events on inpatient wards from January 2005 to December 2013. A negative binomial regression model was used to estimate the 2012 United States incidence and a multivariable logistic regression model was used to examine time trends and characteristics associated with in-hospital mortality.

Results: There were 13,086 index events from 320 hospitals included in the analysis. Using 2012 data, the estimated number of events in the United States was 44,551 (95%CI: 25,170-95,371). The in-hospital mortality for the entire cohort was 39.4% (95%CI: 38.5, 40.2) and rose to 82.6% (95%CI: 79.9, 85.2) for events leading to cardiac arrest. There was a decrease in in-hospital mortality over time (48.3% in 2005 to 34.5% in 2013, p<0.001). Characteristics associated with mortality included agonal breathing, hypotension and septicemia.

Conclusions: Acute respiratory events on inpatient wards in the US is common with an associated in-hospital mortality of approximately 40% that has been decreasing over the past decade. Multiple factors were associated with in-hospital mortality.

Keywords: Epidemiology; Intubation; Pulmonary ventilation; Respiratory insufficiency; Survival.

Publication types

  • Multicenter Study

MeSH terms

  • Age Distribution
  • Aged
  • Cardiopulmonary Resuscitation / mortality
  • Female
  • Heart Arrest / mortality*
  • Hospital Mortality*
  • Hospitals / statistics & numerical data
  • Humans
  • Incidence
  • Logistic Models
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care
  • Prospective Studies
  • Registries
  • Respiratory Insufficiency / mortality*
  • United States / epidemiology