Targeting Adipose Tissue in the Treatment of Obesity-Associated Diabetes

Nat Rev Drug Discov. 2016 Sep;15(9):639-660. doi: 10.1038/nrd.2016.75. Epub 2016 Jun 3.

Abstract

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 diabetes mellitus (T2DM). Although several US-approved treatments for obesity and T2DM exist, these are limited by adverse effects and a lack of effective long-term glucose control. In this Review, we provide an overview of the role of adipose tissue in metabolic homeostasis and assess emerging novel therapeutic strategies targeting adipose tissue, including adipokine-based strategies, promotion of white adipose tissue beiging as well as reduction of inflammation and fibrosis.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / drug effects*
  • Adipose Tissue / pathology
  • Adipose Tissue / physiopathology
  • Animals
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Homeostasis / drug effects
  • Humans
  • Insulin Resistance
  • Obesity / drug therapy*
  • Obesity / pathology*
  • Obesity / physiopathology