Dangerous Entrapment for NRF2

Cell. 2016 Jun 2;165(6):1312-1313. doi: 10.1016/j.cell.2016.05.061.


Progerin, a mutated lamin A, causes the severe premature-aging syndrome Hutchinson-Gilford progeria (HGPS). Kubben et al. present a driving mechanism for HGPS involving trapping of NRF2 at the nuclear periphery by progerin. This local restriction results in impaired NRF2 signaling and chronic oxidative stress.

Publication types

  • Comment

MeSH terms

  • Cell Nucleus / metabolism
  • Humans
  • Lamin Type A / metabolism*
  • Nuclear Proteins / metabolism
  • Oxidative Stress
  • Progeria / metabolism*
  • Protein Precursors / metabolism


  • Lamin Type A
  • Nuclear Proteins
  • Protein Precursors