Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 87 (12), 1368-1374

Acetylcholinesterase Inhibitors Are Associated With Weight Loss in Older People With Dementia: A Systematic Review and Meta-Analysis

Affiliations
Review

Acetylcholinesterase Inhibitors Are Associated With Weight Loss in Older People With Dementia: A Systematic Review and Meta-Analysis

Pinar Soysal et al. J Neurol Neurosurg Psychiatry.

Abstract

We conducted a systematic review and meta-analysis investigating the influence of acetylcholinesterase inhibitors (AChEIs) therapy on nutritional status and weight across observational and interventional studies. Two authors searched major electronic databases from inception until 10/14/2015 for longitudinal, open-label and randomised double-blind placebo controlled (randomised controlled trials (RCTs)) studies of AChEIs in patients with dementia reporting nutritional status outcome data. Out of 3551 initial hits, 25 studies (12 open-label trials, 9 RCTs and 4 longitudinal studies) including 10 792 patients with dementia were meta-analysed. In longitudinal studies (median follow-up 6 months), a significant cumulative incidence of weight loss between baseline and follow-up evaluation was observed (studies=2; 5%; 95% CI 1% to 34%, p<0.0001; I2=95%). These findings were confirmed in open-label trials (6%; 95% CI 4% to 7%, p<0.0001; I2=78%). In 9 RCTs (median follow-up 5 months), those taking AChEIs more frequently experienced weight loss than participants taking placebo (OR=2.18; 95% CI 1.50 to 3.17, p<0.0001; I2=29%). AChEIs therapy contributes to weight loss in patients with dementia, with a 2-fold increased risk observed in the meta-analysis of RCTs. Clinicians should carefully consider the benefit and risk of prescribing AChEIs. Nutritional status should be routinely evaluated in patients with dementia treated with AChEIs.

Keywords: ALZHEIMER'S DISEASE; DEMENTIA; GERIATRICS; META-ANALYSIS.

Similar articles

See all similar articles

Cited by 10 PubMed Central articles

See all "Cited by" articles

Substances

LinkOut - more resources

Feedback