Intrahepatic cholestasis of pregnancy: Recent advances

Clin Dermatol. 2016 May-Jun;34(3):327-34. doi: 10.1016/j.clindermatol.2016.02.004. Epub 2016 Feb 10.


Intrahepatic cholestasis of pregnancy, also known as obstetric cholestasis, is a pruritic condition of pregnancy characterized by an underlying elevation in circulating bile acids and liver derangement, and associated with adverse fetal outcomes, such as preterm labor and stillbirth. Limited understanding of the underlying pathophysiology and mechanisms involved in adverse outcomes has previously restricted treatment options and pregnancy management. Recent advances in these research fields provide tantalizing targets to improve the care of pregnant women affected by this condition.

Publication types

  • Review

MeSH terms

  • Animals
  • Cholestasis, Intrahepatic / complications
  • Cholestasis, Intrahepatic / drug therapy*
  • Cholestasis, Intrahepatic / etiology*
  • Diabetes, Gestational / etiology
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Pregnancy Complications / etiology*
  • Pruritus / etiology*

Supplementary concepts

  • Intrahepatic Cholestasis of Pregnancy