Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 17 (7), 422-33

Determinants of Genetic Diversity

Affiliations
Review

Determinants of Genetic Diversity

Hans Ellegren et al. Nat Rev Genet.

Abstract

Genetic polymorphism varies among species and within genomes, and has important implications for the evolution and conservation of species. The determinants of this variation have been poorly understood, but population genomic data from a wide range of organisms now make it possible to delineate the underlying evolutionary processes, notably how variation in the effective population size (Ne) governs genetic diversity. Comparative population genomics is on its way to providing a solution to 'Lewontin's paradox' - the discrepancy between the many orders of magnitude of variation in population size and the much narrower distribution of diversity levels. It seems that linked selection plays an important part both in the overall genetic diversity of a species and in the variation in diversity within the genome. Genetic diversity also seems to be predictable from the life history of a species.

Similar articles

See all similar articles

Cited by 73 articles

See all "Cited by" articles

References

    1. Trends Ecol Evol. 1996 Oct;11(10):424-9 - PubMed
    1. Nature. 2016 Mar 10;531(7593):233-6 - PubMed
    1. Genome Res. 2015 Nov;25(11):1656-65 - PubMed
    1. Nature. 2011 Jul 13;475(7357):493-6 - PubMed
    1. Genet Res. 1996 Oct;68(2):131-49 - PubMed

LinkOut - more resources

Feedback