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. 2016 Jul 13;8(27):17047-59.
doi: 10.1021/acsami.6b02936. Epub 2016 Jun 30.

A Fluorescent Polymer Probe With High Selectivity Toward Vascular Endothelial Cells for and Beyond Noninvasive Two-Photon Intravital Imaging of Brain Vasculature

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A Fluorescent Polymer Probe With High Selectivity Toward Vascular Endothelial Cells for and Beyond Noninvasive Two-Photon Intravital Imaging of Brain Vasculature

B Mettra et al. ACS Appl Mater Interfaces. .

Abstract

A chromophore-engineering strategy that relies on the introduction of a ground-state distortion in a quadrupolar chromophore was used to obtain a quasi-quadrupolar chromophore with red emission and large two-photon absorption (2PA) cross-section in polar solvents. This molecule was functionalized with water-solubilizing polymer chains. It constitutes not only a remarkable contrast agent for intravital two-photon microscopy of the functional cerebral vasculature in a minimally invasive configuration but presents intriguing endothelial staining ability that makes it a valuable probe for premortem histological staining.

Keywords: TD-DFT; fluorescence; intravital microscopy; near infrared; star-shaped polymer; two-photon absorption.

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