Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network

Trends Cell Biol. 2016 Sep;26(9):694-704. doi: 10.1016/j.tcb.2016.05.003. Epub 2016 Jun 4.


The Hippo signaling network integrates diverse upstream signals to control cell fate decisions and regulate organ growth. Recent studies have provided new insights into the cellular organization of Hippo signaling, its relationship to cell-cell junctions, and how the cytoskeleton modulates Hippo signaling. Cell-cell junctions serve as platforms for Hippo signaling by localizing scaffolding proteins that interact with core components of the pathway. Interactions of Hippo pathway components with cell-cell junctions and the cytoskeleton also suggest potential mechanisms for the regulation of the pathway by cell contact and cell polarity. As our understanding of the complexity of Hippo signaling increases, a future challenge will be to understand how the diverse inputs into the pathway are integrated and to define their respective contributions in vivo.

Keywords: Hippo; cell junctions; cytoskeleton; mechanical force; signaling.

Publication types

  • Review

MeSH terms

  • Actins / metabolism
  • Animals
  • Cytoskeleton / metabolism*
  • Extracellular Matrix / metabolism
  • Humans
  • Intercellular Junctions / metabolism
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction*


  • Actins
  • Protein-Serine-Threonine Kinases