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. 2016 Sep;85:18-25.
doi: 10.1016/j.cyto.2016.05.023. Epub 2016 Jun 4.

IL-36 Receptor Is Expressed by Human Blood and Intestinal T Lymphocytes and Is Dose-Dependently Activated via IL-36β and Induces CD4+ Lymphocyte Proliferation

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IL-36 Receptor Is Expressed by Human Blood and Intestinal T Lymphocytes and Is Dose-Dependently Activated via IL-36β and Induces CD4+ Lymphocyte Proliferation

Rafael Penha et al. Cytokine. .

Abstract

We show that IL-36R is expressed by T (CD4+ and CD8+) and B (CD19+) lymphocytes in human blood and also by CD4+ T lymphocytes in the intestinal lamina propria. IL-36R protein was mostly stored in the cytoplasm of CD4 lymphocytes and B cells, during steady state conditions and the greatest expression of IL-36R mRNA was measured in CD4+ (T helper) lymphocytes. IL-36 β, which functions via IL-36R induced rapid and significant (P<0.05) proliferation of CD4+ lymphocytes, within 48h. IL-36R expression was also maintained on the surface of circulating CD4+ lymphocytes which enter the intestinal lamina propria. In conclusion our study is the first to show that (1) all human blood lymphocytes express IL-36R; (2) IL-36R expression is maintained by circulating CD4+ lymphocytes which enter the intestinal lamina propria and (3) IL-36R/IL-36 β induces rapid CD4 lymphocyte proliferation. The possible significance of these results in the context of human disease is discussed.

Keywords: Human; IL-36; IL-36R; Lymphocyte.

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