Cyclovirus Vietnam DNA in immunodeficient patients

J Clin Virol. 2016 Aug:81:12-5. doi: 10.1016/j.jcv.2016.05.011. Epub 2016 May 20.


Background: Cyclovirus Vietnam (CyCV-VN) is a CyCV detected in 2013 from cerebrospinal fluid (CSF) samples of patients with neurological disorders. Information on prevalence, pathogenesis and disease association of CyCV-VN is still very patchy.

Objectives and study design: In this study, we have used a PCR assay targeting the Rep gene to investigate the prevalence of CyCV-VN infection in blood and CSF samples of 346 Italian subjects.

Results: Overall, 7% of blood samples were positive for CyCV-VN while the virus was not detected in any of the CSF samples. The prevalence of CyCV-VN was relatively high in HIV positive patients (21%), modest in patients with HBV or HCV infection (6%), and low in transplant recipient patients (2%). Positive patients showed low levels of CyCV-VN viremia. The virus was not detected in serum samples from healthy individuals. Longitudinal analysis of serum samples obtained from selected patients showed a stable or transient presence of circulating CyCV-VN.

Conclusions: The present study is the first to demonstrate CyCV-VN DNA circulation in Italy and to cast light on some biological aspects of this novel virus of men.

Keywords: CyCV-VN; Cyclovirus; HIV; Italy; Transplantation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Circoviridae Infections / blood
  • Circoviridae Infections / complications
  • Circoviridae Infections / virology*
  • Circoviridae* / genetics
  • Circoviridae* / isolation & purification
  • Cohort Studies
  • DNA, Viral / blood*
  • Female
  • HIV Infections / complications*
  • Hepatitis B / complications
  • Hepatitis C / complications
  • Humans
  • Immunocompromised Host
  • Italy
  • Male
  • Middle Aged


  • DNA, Viral