The effect of lymphadenectomy on survival and recurrence in patients with ovarian cancer: a systematic review and meta-analysis

Jinhong Zhou; Guoping Shan; Yiwen Chen

doi:10.1093/jjco/hyw068

The effect of lymphadenectomy on survival and recurrence in patients with ovarian cancer: a systematic review and meta-analysis

Jpn J Clin Oncol. 2016 Aug;46(8):718-26. doi: 10.1093/jjco/hyw068. Epub 2016 Jun 6.

Authors

Jinhong Zhou¹, Guoping Shan², Yiwen Chen³

Affiliations

¹ Department of Gynecologic Tumor, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China.
² Department of Gynecologic Tumor, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China shangp@zjcc.org.cn.
³ Statistics with Applications in Medicine, University of Southampton, Southampton, UK.

PMID: 27272175
DOI: 10.1093/jjco/hyw068

Abstract

Objective: Our objective was to perform a meta-analysis examining the effectiveness of lymphadenectomy in patients with ovarian cancer.

Methods: PubMed and CENTRAL databases were searched on 15 November 2015 using the terms 'lymphadenectomy', 'ovarian cancer', 'dissection', 'para-aortic', 'pelvic' and survival. Prospective and retrospective studies comparing the outcomes of surgery with or without lymphadenectomy were included. Outcomes were 5-year overall survival, progression-free survival and recurrence rate.

Results: Of the 556 studies identified, 3 randomized controlled trials and 11 retrospective studies were included. Lymphadenectomy was associated with greater 5-year overall survival than no lymphadenectomy (pooled odds ratio = 1.58, 95% confidence interval: 1.41-1.77, p < 0.001). There was no difference in progression-free survival between the groups (pooled overall survival = 1.62, 95% confidence interval: 0.82-3.21, p = 0.168). Lymphadenectomy was associated with greater progression-free survival in randomized clinical trials (pooled overall survival = 1.57, 95% confidence interval: 1.11-2.21, p = 0.010), but not in retrospective studies. Lymphadenectomy was associated with a significantly lower recurrence rate (pooled overall survival = 0.51, 95% confidence interval: 0.30-0.85, p = 0.011). Lymphadenectomy was associated with greater 5-year overall survival in patients with both early and advanced stage cancer, but was associated with greater progression-free survival and lower recurrence rate only in patients with advanced stage cancer.

Conclusion: Lymphadenectomy is associated with greater 5-year overall survival in patients with early and advanced stage ovarian cancer, but an effect on progression-free survival and recurrence rate was only found in patients with advanced stage ovarian cancer.

Keywords: lymphadenectomy; meta-analysis; ovarian cancer; para-aortic; survival.

Publication types

Meta-Analysis
Review
Systematic Review

MeSH terms

Databases, Factual
Disease-Free Survival
Female
Humans
Lymph Node Excision
Lymphatic Metastasis
Neoplasm Recurrence, Local
Neoplasm Staging
Odds Ratio
Ovarian Neoplasms / mortality
Ovarian Neoplasms / pathology
Ovarian Neoplasms / surgery*