Phytic Acid: From Antinutritional to Multiple Protection Factor of Organic Systems

J Food Sci. 2016 Jun;81(6):R1357-62. doi: 10.1111/1750-3841.13320. Epub 2016 May 3.


Several studies have shown the benefits of natural antioxidants on health and food preservation. Phytic acid (IP6) is a natural antioxidant that is found mainly in cereals and vegetables and, for a long period of time, was considered an antinutritional factor. However, in vitro and in vivo studies have demonstrated its beneficial effects in the prevention and treatment of several pathological conditions and cancer. Despite the numerous benefits of IP6, the signs and intracellular interactions mediated by this antioxidant remain poorly understood. This review describes the main chemical and biological aspects of IP6, as well as its actions in the prevention and treatment of various diseases.

Keywords: antioxidant effect; apoptosis; free radicals; natural antioxidants; phytate.

Publication types

  • Review

MeSH terms

  • Animals
  • Anticarcinogenic Agents / pharmacology
  • Antioxidants / pharmacology
  • Cell Line, Tumor
  • Disease Models, Animal
  • Edible Grain / chemistry
  • Humans
  • Neoplasms / prevention & control
  • Phytic Acid / chemistry*
  • Phytic Acid / pharmacology*
  • Vegetables / chemistry


  • Anticarcinogenic Agents
  • Antioxidants
  • Phytic Acid