Brain edema: a valid endpoint for measuring hepatic encephalopathy?

Metab Brain Dis. 2016 Dec;31(6):1249-1258. doi: 10.1007/s11011-016-9843-9. Epub 2016 Jun 7.


Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease. This metabolic neuropsychiatric syndrome involves a spectrum of symptoms, including cognition impairment, attention deficits and motor dysfunction which eventually can progress to coma and death. Pathologically, HE is characterized by swelling of the astrocytes which consequently leads to brain edema, a common feature found in patients with acute liver failure (ALF) as well as in cirrhotic patients suffering from HE. The pathogenic factors involved in the onset of astrocyte swelling and brain edema in HE are unresolved. However, the role of astrocyte swelling/brain edema in the development of HE remains ambiguous and therefore measuring brain edema as an endpoint to evaluate HE is questioned. The following review will determine the effect of astrocyte swelling and brain edema on neurological function, discuss the various possible techniques to measure brain edema and lastly to propose a number of neurobehavioral tests to evaluate HE.

Keywords: Astrocyte; Brain edema; Hepatic encephalopathy; Magnetic resonance imaging; Neurobehavior.

Publication types

  • Review

MeSH terms

  • Animals
  • Anxiety / diagnosis
  • Anxiety / epidemiology
  • Anxiety / psychology
  • Astrocytes / pathology*
  • Brain Edema / diagnosis*
  • Brain Edema / epidemiology
  • Brain Edema / psychology
  • Disease Progression*
  • Endpoint Determination / methods
  • Endpoint Determination / standards*
  • Hepatic Encephalopathy / diagnosis*
  • Hepatic Encephalopathy / epidemiology
  • Hepatic Encephalopathy / psychology
  • Humans
  • Reproducibility of Results