Abstract
Buthionine sulfoximine (500 mg/kg, i.p.), a glutathione-depleting agent, was found to increase the acute lethal toxicity and urotoxicity induced by ifosfamide in mice.
MeSH terms
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Animals
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Buthionine Sulfoximine
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Cysteamine / toxicity
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Glutathione / metabolism
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Ifosfamide / toxicity*
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Liver / drug effects
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Liver / metabolism
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Male
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Methionine Sulfoximine / analogs & derivatives*
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Methionine Sulfoximine / toxicity
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Mice
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Organ Size / drug effects
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Urinary Bladder / drug effects
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Urologic Diseases / chemically induced*
Substances
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Methionine Sulfoximine
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Buthionine Sulfoximine
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Cysteamine
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Glutathione
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Ifosfamide