Influence of buthionine sulfoximine on the lethality of ifosfamide and ifosfamide-induced urotoxicity in mice

Res Commun Chem Pathol Pharmacol. 1989 Mar;63(3):455-8.

Abstract

Buthionine sulfoximine (500 mg/kg, i.p.), a glutathione-depleting agent, was found to increase the acute lethal toxicity and urotoxicity induced by ifosfamide in mice.

MeSH terms

  • Animals
  • Buthionine Sulfoximine
  • Cysteamine / toxicity
  • Glutathione / metabolism
  • Ifosfamide / toxicity*
  • Liver / drug effects
  • Liver / metabolism
  • Male
  • Methionine Sulfoximine / analogs & derivatives*
  • Methionine Sulfoximine / toxicity
  • Mice
  • Organ Size / drug effects
  • Urinary Bladder / drug effects
  • Urologic Diseases / chemically induced*

Substances

  • Methionine Sulfoximine
  • Buthionine Sulfoximine
  • Cysteamine
  • Glutathione
  • Ifosfamide