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Ability of Pit and Fissure Sealant-containing Amorphous Calcium Phosphate to Inhibit Enamel Demineralization


Ability of Pit and Fissure Sealant-containing Amorphous Calcium Phosphate to Inhibit Enamel Demineralization

Feda I Zawaideh et al. Int J Clin Pediatr Dent.


Aim: To evaluate the effect of amorphous calcium phosphate (ACP)-containing pit and fissure sealant on inhibition of enamel demineralization in vitro.

Materials and methods: Enamel specimens (n = 75) were prepared using freshly extracted noncarious human third molars. Box-shaped cavities (8 × 2 × 2 mm) on the buccal or lingual surfaces were prepared and restored with resin-based sealant (Concise™), ACP-containing sealant (Aegis®) or fluoride-containing sealant (Conseal-F™). The samples were acid challenged in a demineralizing solution of 50 mmol/l lactic acid at pH 5.0 for 4 days. The change in enamel microhardness (ASuH) was calculated. Data were analyzed using one-way analysis of variance (ANOVA) and Tukey's post hoc test.

Results: The mean SuH0 (±SD) (in Vicker's unit) prior to the acid challenge was: Concise™ (318.83 ± 33.86), Aegis® (331.03 ± 21.52), Conseal-F™ (310.12 ± 34.31). Following the acid challenge, the values dropped in all groups and ASuH (±SD) values were 269.17 ± 47.49, 151.39 ± 23.96 and 175.79 ± 32.39 respectively.

Conclusion: The ACP-containing pit and fissure sealant has the potential to inhibit enamel demineralization. How to cite this article: Zawaideh FI, Owais AI, Kawaja W. Ability of pit and fissure sealant-containing amorphous calcium phosphate to inhibit enamel demineralization. Int J Clin Pediatr Dent 2016;9(1):10-14.

Keywords: Aegis®; Amorphous calcium phosphate; Demi-neralization; Pit and fissure sealant; Surface microhardness..

Conflict of interest statement

Source of support: This Study was funded by the Deanship of Research at Jordan University of Science and Technology (Grant 20120058).

Conflict of interest: None

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