Brief Report: Plasma Concentrations of Perfluorooctane Sulfonamide and Time-to-pregnancy Among Primiparous Women

Epidemiology. 2016 Sep;27(5):712-5. doi: 10.1097/EDE.0000000000000524.


Background: A previous study reported a negative association between perfluorooctane sulfonamide (PFOSA) concentrations and fecundability.

Methods: We examined this association among women enrolled in the Norwegian Mother and Child Cohort Study (MoBa), in 2003-2004. This analysis was restricted to 451 primiparous women to avoid bias due to previous pregnancy. Self-reported time-to-pregnancy (TTP) and plasma were obtained around 18 weeks of gestation. Approximately half of the women had measurable PFOSA levels; missing values were multiply imputed. We used the logistic analogue of discrete-time survival analysis to examine the adjusted association between PFOSA, other perfluoroalkyl substances, and TTP.

Results: The median-measured PFOSA concentration was 0.03 ng/ml (interquartile range = 0.02, 0.07). The age and body mass index-adjusted association between an interquartile distance increase in PFOSA and TTP was 0.91 (95% confidence interval = 0.71, 1.17). Imputation of missing PFOSA resulted in similar estimates. No association was observed with other perfluoroalkyl substances.

Conclusion: Based on a weakly decreased fecundability odds ratio, we found only limited support for an association between plasma PFOSA concentrations and TTP among primiparous women. See Video Abstract at

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Body Mass Index
  • Chromatography, Liquid
  • Cohort Studies
  • Environmental Exposure
  • Female
  • Fluorocarbons / blood*
  • Humans
  • Logistic Models
  • Mass Spectrometry
  • Maternal Age*
  • Norway
  • Odds Ratio
  • Parity*
  • Pregnancy
  • Pregnancy Trimester, Second
  • Prospective Studies
  • Self Report
  • Sulfonamides / blood*
  • Time-to-Pregnancy*
  • Young Adult


  • Fluorocarbons
  • Sulfonamides
  • perfluorooctanesulfonamide