Efficacy of chlorophyll c2 for seasonal allergic rhinitis: single-center double-blind randomized control trial

Eur Arch Otorhinolaryngol. 2016 Dec;273(12):4289-4294. doi: 10.1007/s00405-016-4133-z. Epub 2016 Jun 9.


Chlorophyll c2 extracted from Sargassum horneri improved allergic symptoms in an animal model of allergic rhinitis. In the present study, we explored the efficacy of chlorophyll c2 in patients with seasonal allergic rhinitis. This was a single-center, randomized, double-blind placebo-controlled trial. Sixty-six patients aged 20-43 years, each with a 2-year history of seasonal allergic rhinitis, were randomly assigned to receive either a single daily dose (0.7 mg) of chlorophyll c2 or placebo for 12 weeks. The use of medications including H1-antihistamines and topical nasal steroids was recorded by rescue medication scores (RMSs) noted after 4, 8, and 12 weeks of treatment. Disease-specific quality of life was measured using the Japan Rhinitis Quality of Life Questionnaire (JRQLQ) both before and after 4, 8, and 12 weeks of treatment. The RMS at 8 weeks was significantly better in the chlorophyll c2 than the placebo group (mean RMS difference = -3.09; 95 % confidence interval = -5.96 to -0.22); the mean RMS at 4 weeks was only slightly better in the chlorophyll c2 group. The JRQLQ scores did not differ significantly between the two groups. Chlorophyll c2 would have a potential to be an alternative treatment for allergic rhinitis.

Keywords: Allergic rhinitis; Chlorophyll c2; Complementary therapies; Sargassum horneri; Seaweed.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Chlorophyll / therapeutic use*
  • Double-Blind Method
  • Female
  • Humans
  • Japan
  • Male
  • Quality of Life
  • Rhinitis, Allergic, Seasonal / therapy*
  • Sargassum*
  • Single-Blind Method
  • Surveys and Questionnaires
  • Time Factors
  • Young Adult


  • Chlorophyll
  • chlorophyll c