Abstract
This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The rutin content in tartary buckwheat sprout (TBS) is five times higher than that found in common buckwheat sprout (CBS) as evident from high-performance liquid chromatography analysis. Administration of either rutin or TBS ethanolic extract to diabetes mice decreased the serum glucose level significantly. Rutin down-regulated the expression levels of protein-tyrosine phosphatase 1B; it is negative regulator of insulin pathway, both transcriptionally and translationally in myocyte C2C12 in a dose-dependent manner. In conclusion, rutin can play a critical role in down-regulation of serum glucose level in type 2 diabetes.
MeSH terms
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3T3-L1 Cells
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Animals
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Biomarkers / blood
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Blood Glucose / drug effects*
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Blood Glucose / metabolism
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Diabetes Mellitus, Type 2 / blood
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Diabetes Mellitus, Type 2 / drug therapy*
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Diabetes Mellitus, Type 2 / genetics
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Down-Regulation
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Fagopyrum / chemistry
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Hypoglycemic Agents / isolation & purification
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Hypoglycemic Agents / pharmacology*
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Mice
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Mice, Inbred C57BL
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Myoblasts, Skeletal / drug effects
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Myoblasts, Skeletal / enzymology
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Phytotherapy
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Plants, Medicinal
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Protein Tyrosine Phosphatase, Non-Receptor Type 1 / genetics
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Protein Tyrosine Phosphatase, Non-Receptor Type 1 / metabolism
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Rutin / isolation & purification
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Rutin / pharmacology*
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Seedlings
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Time Factors
Substances
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Biomarkers
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Blood Glucose
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Hypoglycemic Agents
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Rutin
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Protein Tyrosine Phosphatase, Non-Receptor Type 1
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Ptpn1 protein, mouse