Hyaluronic acid: Perspectives in dentistry. A systematic review

Int J Immunopathol Pharmacol. 2016 Dec;29(4):572-582. doi: 10.1177/0394632016652906. Epub 2016 Jun 8.


To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the soft periodontal tissue, gingiva, and periodontal ligament as well as to the hard tissue such as alveolar bone and cementum. Topical hyaluronic acid (HA) has recently been recognized as an adjuvant treatment for chronic inflammatory disease in addition to its use to improve healing after dental procedures. The aim of our work was to systematically review the published literature about potential effects of HA as an adjuvant treatment for chronic inflammatory disease, in addition to its use to improve healing after common dental procedures. Relevant published studies were found in PubMed, Google Scholar, and Ovid using a combined keyword search or medical subject headings. At the end of our study selection process, 25 relevant publications were included, three of them regarding gingivitis, 13 of them relating to chronic periodontitis, seven of them relating to dental surgery, including implant and sinus lift procedures, and the remaining three articles describing oral ulcers. Not only does topical administration of HA play a pivotal key role in the postoperative care of patients undergoing dental procedures, but positive results were also generally observed in all patients with chronic inflammatory gingival and periodontal disease and in patients with oral ulcers.

Keywords: burning mouth; gingivitis; healing; hyaluronan; hyaluronic acid; implant; mucositis; oral mucous regeneration; oral wound; periodontitis; sodium hyaluronate; stomatitis; teeth.

Publication types

  • Editorial
  • Review
  • Systematic Review

MeSH terms

  • Animals
  • Chronic Disease / drug therapy*
  • Dentistry / methods
  • Gingivitis / drug therapy
  • Humans
  • Hyaluronic Acid / therapeutic use*
  • Inflammation / drug therapy*
  • Periodontitis / drug therapy


  • Hyaluronic Acid