Magnetic Multivalent Trehalose Glycopolymer Nanoparticles for the Detection of Mycobacteria

Xuan Chen; Bin Wu; Kalana W Jayawardana; Nanjing Hao; H Surangi N Jayawardena; Robert Langer; Ana Jaklenec; Mingdi Yan

doi:10.1002/adhm.201600071

Magnetic Multivalent Trehalose Glycopolymer Nanoparticles for the Detection of Mycobacteria

Adv Healthc Mater. 2016 Aug;5(16):2007-12. doi: 10.1002/adhm.201600071. Epub 2016 Jun 10.

Authors

Xuan Chen¹, Bin Wu¹, Kalana W Jayawardana¹, Nanjing Hao¹, H Surangi N Jayawardena², Robert Langer², Ana Jaklenec², Mingdi Yan¹

Affiliations

¹ Department of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA.
² David H. Koch Institute of Integrative Cancer Research Centre, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Abstract

A multivalent trehalose-grafted poly(lactic acid) is synthesized and encapsulated with iron oxide magnetic nanoparticles. The magnetic micelles interact with Mycobacterium smegmatis to form orange clusters. Very little particle interaction is found on Staphylococcus epidermidis 35984 or Escherichia coli ORN 208. The presented new approach to the detection of mycobacteria does not require molecular biology reagents or sophisticated instruments.

Keywords: glycopolymer; magnetic micelles; mycobacterium; poly(lactic acid); trehalose.

MeSH terms

Bacterial Typing Techniques / methods*
Escherichia coli / classification
Magnetite Nanoparticles / chemistry*
Mycobacterium smegmatis / classification*
Staphylococcus epidermidis / classification
Trehalose / chemistry*

Substances

Magnetite Nanoparticles
Trehalose

Abstract

MeSH terms

Substances

Grants and funding