Bioavailability of anthocyanins and colonic polyphenol metabolites following consumption of aronia berry extract

Food Chem. 2016 Nov 15;211:860-8. doi: 10.1016/j.foodchem.2016.05.122. Epub 2016 May 19.

Abstract

A single-dose pharmacokinetic trial was conducted in 6 adults to evaluate the bioavailability of anthocyanins and colonic polyphenol metabolites after consumption of 500mg aronia berry extract. UHPLC-MS methods were developed to quantitate aronia berry polyphenols and their metabolites in plasma and urine. While anthocyanins were bioavailable, microbial phenolic catabolites increased ∼10-fold more than anthocyanins in plasma and urine. Among the anthocyanins, cyanidin-3-O-galactoside was rapidly metabolized to peonidin-3-O-galactoside. Aronia polyphenols were absorbed and extensively metabolized with tmax of anthocyanins and other polyphenol catabolites from 1.0h to 6.33h in plasma and urine. Despite significant inter-individual variation in pharmacokinetic parameters, concentrations of polyphenol metabolites in plasma and urine at 24h were positively correlated with total AUC in plasma and urine (r=0.93, and r=0.98, respectively). This suggests that fasting blood and urine collections could be used to estimate polyphenol bioavailability and metabolism after aronia polyphenol consumption.

Keywords: Anthocyanin; Aronia; Cyanidin; Ferulic acid; Metabolism; Pharmacokinetic; Polyphenol; UHPLC-MS.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Anthocyanins / administration & dosage
  • Anthocyanins / metabolism*
  • Biological Availability
  • Colon / metabolism*
  • Eating / physiology
  • Female
  • Fruit / chemistry
  • Fruit / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Photinia / metabolism*
  • Pilot Projects
  • Plant Extracts / administration & dosage
  • Plant Extracts / metabolism*
  • Polyphenols / metabolism*
  • Young Adult

Substances

  • Anthocyanins
  • Plant Extracts
  • Polyphenols