High field magnetic resonance imaging of rodents in cardiovascular research

Basic Res Cardiol. 2016 Jul;111(4):46. doi: 10.1007/s00395-016-0565-2. Epub 2016 Jun 10.

Abstract

Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing specific investigation of cardiac anatomy, global and regional function, viability, perfusion or vascular parameters. The aim of this report is to provide a review of the various sequences and techniques available to image mice on 7-11.7 T magnets and relevant to the clinical setting in humans. Specific technical aspects due to the rise of the magnetic field are also discussed.

Keywords: Cardiovascular diseases; High field; MRI; Mouse.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cardiovascular Diseases / diagnostic imaging*
  • Disease Models, Animal
  • Heart / diagnostic imaging*
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Mice