The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations

Pigment Cell Melanoma Res. 2016 Sep;29(5):590-7. doi: 10.1111/pcmr.12498. Epub 2016 Aug 3.


The remarkable success of immune therapies emphasizes the need for immune-competent cancer models. Elegant genetically engineered mouse models of a variety of cancers have been established, but their effective use is limited by cost and difficulties in rapidly generating experimental data. Some mouse cancer cell lines are transplantable to immunocompetent host mice and have been utilized extensively to study cancer immunology. Here, we describe the Yale University Mouse Melanoma (YUMM) lines, a comprehensive system of mouse melanoma cell lines that are syngeneic to C57BL/6, have well-defined human-relevant driver mutations, and are genomically stable. This will be a useful tool for the study of tumor immunology and genotype-specific cancer biology.

Keywords: YUMM; cancer immunology; cell lines; melanoma; mouse models.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Biomarkers, Tumor / genetics*
  • Cell Line, Tumor
  • Disease Models, Animal*
  • Drug Resistance, Neoplasm / genetics*
  • Female
  • Humans
  • Immunity, Cellular / genetics*
  • Male
  • Melanoma, Experimental / drug therapy
  • Melanoma, Experimental / genetics*
  • Melanoma, Experimental / immunology*
  • Melanoma, Experimental / pathology
  • Mice
  • Mice, Congenic
  • Mice, Inbred C57BL
  • Mutation*


  • Antineoplastic Agents
  • Biomarkers, Tumor