Effect of physical activity on IGF-1 and IGFBP levels in the context of civilization diseases prevention

Rocz Panstw Zakl Hig. 2016;67(2):105-11.


Background: Insulin-like growth factor 1 (IGF-1) is known as somatomedin C. This polypeptide hormone is functionally and structurally similar to insulin. IGF-1 effects on tissue by the IGF-1R and the insulin-like growth factor-binding protein also known as IGFBP. Abnormal IGF-1 and IGFBP signaling are positively correlated with a high risk of selected civilization diseases development. Physical inactivity is a one of the main causes of majority of chronic diseases and it is associated with eg. IGF-1 and IGFBPs level.

Objective: The aim of the study was to explanation the effect of physical activity on IGF-1 and its binding protein - IGFB- Ps concentration in the context of selected civilization diseases prevention. The review of clinical trial.

Material and methods: The review of articles had published in databases: MEDLINE, EMBASE, Scopus and Web of Science until December 2015. The selected prospective studies about the effect of exercise on IGF-1 level and its binding protein IGFBP in the context of selected civilization diseases prevention were collected.

Results: The majority of the included studies indicate that mechanical loading is a key mechanism linking IGF-1/IGFBPs con- centration and selected chronic diseases development. The duration and intensity of physical activity have a significant impact on IGF-1 and IGFBP serum. The highest concentration of IGF-1 in serum was after eccentric training. "Overtraining" increases unfavorable and unbound IGF-1 levels and contributes to the increased incidence of hormone-cancer and osteoarthritis.

Conclusions: Irregularity of the GH/IGF-1 axis may affect on the development of rheumatic diseases, cardiovascular dis- eases (regulate cardiac growth and metabolism) and metabolic syndrome.

MeSH terms

  • Cardiovascular Diseases / prevention & control
  • Chronic Disease / prevention & control*
  • Diabetes Mellitus, Type 2 / prevention & control
  • Exercise / physiology*
  • Humans
  • Insulin-Like Growth Factor Binding Protein 1 / metabolism*
  • Insulin-Like Growth Factor I / metabolism*
  • Motor Activity
  • Neoplasms / prevention & control


  • Insulin-Like Growth Factor Binding Protein 1
  • Insulin-Like Growth Factor I