Organ-specific antibodies against ovary in patients with systemic lupus erythematosus

Am J Obstet Gynecol. 1989 May;160(5 Pt 1):1227-9. doi: 10.1016/0002-9378(89)90200-7.


We studied whether patients with systemic lupus erythematosus can have organ-specific antibodies directed against ovaries. With a recently developed enzyme-linked immunosorbent assay system that uses both a soluble and an extractable corpus luteum antigen fraction, we detected both IgG and IgM antibodies in the sera of patients with systemic lupus erythematosus (16 of 19, 84%). The highest levels of IgG antibodies were seen when the extractable organ fraction (ST80) was used as the antigen.

Publication types

  • Comparative Study

MeSH terms

  • Antibodies / analysis*
  • Antibody Specificity*
  • Cardiolipins / immunology
  • Cross Reactions
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / immunology*
  • Ovary / immunology*


  • Antibodies
  • Cardiolipins