Lymphocyte proliferative responses of patients with ocular toxoplasmosis to parasite and retinal antigens

Am J Ophthalmol. 1989 Jun 15;107(6):632-41. doi: 10.1016/0002-9394(89)90260-2.


In vitro lymphocyte proliferative responses to purified toxoplasma antigens and the retinal S-antigen were evaluated in 40 patients with ocular toxoplasmosis; 16 (40%) had a positive in vitro response to the retinal S-antigen. The proliferative responses to the 2G11 (p22) toxoplasma membrane antigen approached that of a crude antigen preparation of Toxoplasma gondii, whereas the response to the 1E11 immunodominant p30 membrane antigen was considerably less striking. HLA typing was also performed, and none correlated to S-antigen or toxoplasma reactivity. The evidence strongly suggests that patients with a clearly infectious ocular disorder may have part of their disease mediated by a putative autoimmune mechanism. An immune response to the 2G11 toxoplasma antigen may increase the risk of developing ocular disease or a substrain of toxoplasma with 2G11 as its immunodominant membrane antigen may have a greater affinity for the retina.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Animals
  • Antigens / immunology*
  • Antigens, Protozoan / immunology*
  • Antigens, Surface / immunology*
  • Arrestin
  • Child
  • Child, Preschool
  • Eye Proteins / immunology*
  • Female
  • HLA Antigens / immunology
  • Humans
  • Lymphocyte Activation*
  • Male
  • Middle Aged
  • Phenotype
  • Toxoplasma / immunology*
  • Toxoplasmosis, Ocular / immunology*


  • Antigens
  • Antigens, Protozoan
  • Antigens, Surface
  • Arrestin
  • Eye Proteins
  • HLA Antigens