Diagnostic ability of magnifying endoscopy with blue laser imaging for early gastric cancer: a prospective study

Gastric Cancer. 2017 Mar;20(2):297-303. doi: 10.1007/s10120-016-0620-6. Epub 2016 Jun 13.


Background: Blue laser imaging (BLI) is a new image-enhanced endoscopy technique that utilizes a laser light source developed for narrow-band light observation. The aim of this study was to evaluate the usefulness of BLI for the diagnosis of early gastric cancer.

Methods: This single center prospective study analyzed 530 patients. The patients were examined with both conventional endoscopy with white-light imaging (C-WLI) and magnifying endoscopy with BLI (M-BLI) at Kyoto Prefectural University of Medicine between November 2012 and March 2015. The diagnostic criteria for gastric cancer using M-BLI included an irregular microvascular pattern and/or irregular microsurface pattern, with a demarcation line according to the vessel plus surface classification system. Biopsies of the lesions were taken after C-WLI and M-BLI observation. The primary end point of this study was to compare the diagnostic performance between C-WLI and M-BLI.

Results: We analyzed 127 detected lesions (32 cancers and 95 non-cancers). The accuracy, sensitivity, and specificity of M-BLI diagnoses were 92.1, 93.8, and 91.6 %, respectively. On the other hand, the accuracy, sensitivity, and specificity of C-WLI diagnoses were 71.7, 46.9, and 80.0 %, respectively.

Conclusions: M-BLI had improved diagnostic performance for early gastric cancer compared with C-WLI. These results suggested that the diagnostic effectiveness of M-BLI is similar to that of magnifying endoscopy with narrow-band imaging (M-NBI).

Keywords: Blue laser imaging; Early gastric cancer; Endoscopic diagnosis; Magnifying endoscopy; VS classification.

Publication types

  • Clinical Trial

MeSH terms

  • Adenocarcinoma / diagnosis*
  • Adenocarcinoma / diagnostic imaging
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Early Detection of Cancer
  • Female
  • Follow-Up Studies
  • Gastroscopy / methods*
  • Humans
  • Male
  • Middle Aged
  • Narrow Band Imaging / methods*
  • Neoplasm Staging
  • Prognosis
  • Prospective Studies
  • Stomach Neoplasms / diagnosis*
  • Stomach Neoplasms / diagnostic imaging