The association of age-related macular degeneration and lens opacities in the aged

Am J Public Health. 1989 Jun;79(6):765-9. doi: 10.2105/ajph.79.6.765.


Data from 3,087 persons age 45 or older in the National Health and Nutrition Survey, 1971-74, showed that subjects with lens opacifying disease had an increased odds for age-related macular degeneration (AMD) compared to those who had no lens opacities. The crude odds ratio for aphakic patients was 4.6 (95% CI = 2.5, 8.6). The association remained after controlling for age, sex, and systolic blood pressure (a common risk factor) in a logistic regression model. These data are consistent with the hypothesis that light-induced damage may contribute to both lens and retinal disease and suggest that cataract extraction without implantation of ultra-violet/blue light absorbing intraocular lens may place subjects at increased risk of AMD.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Aging / pathology*
  • Cataract / complications
  • Cataract / epidemiology*
  • Female
  • Health Surveys
  • Humans
  • Macular Degeneration / complications
  • Macular Degeneration / epidemiology*
  • Male
  • Middle Aged
  • Regression Analysis
  • Risk Factors
  • United States