[Molecular Mechanism of Glycoprotein-induced Cell-Cell Fusion of Herpesviruses]

Bing Du Xue Bao. 2016 Jan;32(1):101-7.
[Article in Chinese]

Abstract

Herpesviridae is a large family comprising linear, double-stranded DNA viruses. Herpesviridae contains three subfamilies: α-, β- and γ-herpesviruses. The glycoproteins gB, gH and gL of each subfamily form the "core fusion function" in cell-cell fusion. Other herpesviruses also need additional glycoproteins to promote fusion, such as gD of the Herpes simplex virus, gp42 of the Epstein-Barr virus, and gO or UL128-131 of the Human cytomegalovirus. In contrast, glycoproteins gM or gM/gN of herpesvirus inhibit fusion. We describe the molecular mechanisms of glycoprotein-induced fusion and entry of herpesviruses. It will be helpful to further study the pathogenic mechanism of herpesvirus.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Fusion
  • Glycoproteins / genetics
  • Glycoproteins / metabolism*
  • Herpesviridae / genetics
  • Herpesviridae / metabolism*
  • Herpesviridae Infections / physiopathology
  • Herpesviridae Infections / virology*
  • Humans
  • Viral Proteins / genetics
  • Viral Proteins / metabolism*

Substances

  • Glycoproteins
  • Viral Proteins