Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics

Trends Biotechnol. 2016 Sep;34(9):722-732. doi: 10.1016/j.tibtech.2016.05.013. Epub 2016 Jun 10.


Improving the ability to predict the efficacy and toxicity of drug candidates earlier in the drug discovery process will speed up the introduction of new drugs into clinics. 3D in vitro systems have significantly advanced the drug screening process as 3D tissue models can closely mimic native tissues and, in some cases, the physiological response to drugs. Among various in vitro systems, bioprinting is a highly promising technology possessing several advantages such as tailored microarchitecture, high-throughput capability, coculture ability, and low risk of cross-contamination. In this opinion article, we discuss the currently available tissue models in pharmaceutics along with their limitations and highlight the possibilities of bioprinting physiologically relevant tissue models, which hold great potential in drug testing, high-throughput screening, and disease modeling.

Keywords: bioprinting; drug screening; high-throughput assays; organ-on-chip models.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Bioprinting*
  • Drug Discovery*
  • High-Throughput Screening Assays*
  • Humans
  • Models, Biological*
  • Tissue Array Analysis*