Monocyte to high-density lipoprotein cholesterol ratio is predictive of in-hospital and five-year mortality in ST-segment elevation myocardial infarction

Cardiol J. 2016;23(5):505-512. doi: 10.5603/CJ.a2016.0026. Epub 2016 Jun 14.

Abstract

Background: We assessed the value of monocyte to high-density lipoprotein cholesterol ratio (MHR) in predicting in-hospital and 5-year mortality and major adverse cardiovascular events (MACE) in ST-segment elevation myocardial infarction (STEMI) patients.

Methods: A group of 1,598 patients were enrolled and divided into tertiles according to MHR values. The effects of different variables on clinical outcomes were assessed by Cox regression analysis.

Results: MHR was found as an independent predictor of in-hospital mortality (HR = 3.745, 95% CI 1.308-5.950), in-hospital MACE (HR 1.501, 95% CI 1.015-1.993, p = 0.022) and 5-year mortality (HR = 2.048, 95% CI 1.225-4.091, p = 0.014) and 5-year MACE (HR 1.285, 95% CI 1.064-1.552, p = 0.009).

Conclusions: MHR is an independent predictor of in-hospital and long term mortality and MACE in STEMI.

Keywords: ST-segment elevation myocardial infarction; high density lipoprotein cholesterol; monocyte; monocyte to high-density lipoprotein ratio.

MeSH terms

  • Adult
  • Biomarkers / blood
  • Cholesterol, HDL / blood*
  • Coronary Angiography
  • Electrocardiography
  • Female
  • Follow-Up Studies
  • Hospital Mortality / trends
  • Humans
  • Male
  • Middle Aged
  • Monocytes / pathology*
  • Retrospective Studies
  • Risk Factors
  • ST Elevation Myocardial Infarction / blood*
  • ST Elevation Myocardial Infarction / diagnosis
  • ST Elevation Myocardial Infarction / mortality
  • Survival Rate / trends
  • Time Factors
  • Turkey / epidemiology

Substances

  • Biomarkers
  • Cholesterol, HDL